A worldwide e-Infrastructure for NMR and structural biology

Exploring Nature's Molecular Machines

Event Date: 
Mon, 2014-07-07 (All day) - Fri, 2014-07-18 (All day)
  • Course location(s) Utrecht (Utrecht city campus), The Netherlands
  • Credits 3.0 ECTS credits + Certificate of Attendance
  • Organizing institution Utrecht University, Faculty of Science (UU)
  • Course fee (incl. housing) € 835
  • Level Master level

We will focus on the chemical principles underlying protein structure and function and how proteins fold and assemble into complex “molecular machines”. The students will be introduced to advanced methods in structural and molecular biology and biophysics for decoding the cellular protein machinery at atomic resolution. We will examine how malfunction of specific components can lead to systemic failure and disease. The school will combine theory (lectures, tutorials) with experiments in research laboratories.

 

This course focuses on the chemical principles underlying protein structure and function and how proteins form an assembly of “molecular machines” that work together to sustain the living state. We will explore how proteins “know” what shape they should fold up into following their synthesis, how they cluster into dynamic macromolecular complexes, and how these complexes communicate to form “social” networks that enable cells to move, replicate, signal, and execute other vital processes. The students will be introduced to advanced methods in structural and molecular biology and biophysics for decoding the cellular protein machinery at atomic resolution, and examine how malfunction of specific components can lead to systemic failure and disease. The school will combine theory (lectures, tutorials) with experiments in research laboratories (including e.g. a 900 MHz NMR spectrometer, the Netherlands Proteomics Center and semi-automated protein crystallization facility). We also schedule a visit to a leading biotech company.

For additional info see: http://www.utrechtsummerschool.nl/courses/science/exploring-natures-molecular-machines

 

Cite WeNMR/WestLife

 
Usage of the WeNMR/WestLife portals should be acknowledged in any publication:
 
"The FP7 WeNMR (project# 261572) and H2020 West-Life (project# 675858) European e-Infrastructure projects are acknowledged for the use of their web portals, which make use of the EGI infrastructure and DIRAC4EGI service with the dedicated support of CESNET-MetaCloud, INFN-PADOVA, NCG-INGRID-PT, RAL-LCG2, TW-NCHC, SURFsara and NIKHEF, and the additional support of the national GRID Initiatives of Belgium, France, Italy, Germany, the Netherlands, Poland, Portugal, Spain, UK, South Africa, Malaysia, Taiwan and the US Open Science Grid."
 
And the following article describing the WeNMR portals should be cited:
Wassenaar et al. (2012). WeNMR: Structural Biology on the Grid.J. Grid. Comp., 10:743-767.

EGI-approved

The WeNMR Virtual Research Community has been the first to be officially recognized by the EGI.

European Union

WeNMR is an e-Infrastructure project funded under the 7th framework of the EU. Contract no. 261572

WestLife, the follow up project of WeNMR is a Virtual Research Environment e-Infrastructure project funded under Horizon 2020. Contract no. 675858

West-Life