Thu, 2012-11-29 (All day) - Thu, 2012-12-06 (All day)
The main objective of this EMBO course is to teach the young PhD students and postdocs
from all areas of biology the methods applicable to study biological macromolecules
in solution. We aim at a comprehensive coverage of the field including the major
structural and biophysical techniques employed for the characterization of high
and low resolution structure and structural transitions, macromolecular complex
formation, protein folding and stability, protein-protein and protein-ligand interactions and enzymatic
mechanisms. The Course will include lectures on small-angle X-ray and neutron scattering (SAXS/SANS),
nuclear magnetic resonance (NMR), static and dynamic light scattering (SLS/DLS),
analytical ultracentrifugation (AUC), surface plasmon resonance (SPR), differential and
isothermal calorimetry (DSC/ITC) and spectroscopic approaches. Bioinformatic tools
to analyze protein-protein interactions will also be considered, and the joint use of
the solution characterization methods with the major non-solution structural techniques,
macromolecular crystallography (MX), electron microscopy (EM), mass spectrometry (MS)
and with the in situ methods will be covered. Special attention will be paid to
interdisciplinary approaches, where the synergistic use of complementary techniques
leads to a comprehensive description of macromolecular systems.
From the Indian side, the Course will be co-organized by the Centre for Cellular and
Molecular Biology (CCMB), Hyderabad, and the Tata Institute of Fundamental Research
(TIFR), Mumbai. The course will be held at CCMB in Hyderabad immediately following an
International meeting on biology (25-27 November 2012), commemorating 25 years of
moving into the current CCMB R&D complex.
A maximum of 40 participants will be selected to attend the course.
No registration fee will be requested from the academic participants.
Applicants from industry are expected to pay a 1000 Euro fee.
The Course is oriented towards applicants active in structural biology,
mostly late Ph.D. students and early post-docs but more senior scientists,
depending on circumstances, could also participate.
Students working in India or Indian students working abroad will be
given preference but all applications are welcome at
Application deadline for the Course: September, 17th, 2012